Role of HIF-1 in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells
نویسندگان
چکیده
Ruifeng Zhang, Yingli Wu, Meng Zhao, Chuanxu Liu, Lin Zhou, Shaoming Shen, Shihua Liao, Kun Yang, Qingyun Li, and Huanying Wan Departments of Respiratory Medicine and Gastroenterology, Ruijin Hospital, Medical School of Shanghai Jiaotong University, Shanghai; Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai; and Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China
منابع مشابه
Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells.
Angiotensin-converting enzyme (ACE) enhances the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of hypoxic pulmonary hypertension (HPH). Previous reports have demonstrated that hypoxia upregulates ACE expression, but the underlying mechanism is unknown. Here, we found that ACE is persistently upregulated in PASMCs on the transc...
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